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- Title
Resin from Virola oleifera Protects Against Radiocontrast-Induced Nephropathy in Mice.
- Authors
Bôa, Igor Santos Fonte; Porto, Marcella Leite; Pereira, Ana Claudia Hertel; Ramos, Jean Pierre Louzada; Scherer, Rodrigo; Oliveira, Jairo Pinto; Nogueira, Breno Valentim; Meyrelles, Silvana Santos; Vasquez, Elisardo Corral; Endringer, Denise Coutinho; Pereira, Thiago Melo Costa
- Abstract
Contrast-induced nephropathy (CIN) is an iatrogenic medical event for which there is not yet a successful therapy. Increasing evidence in rodents has suggested that this disease is associated with renal tubular and vascular injury that is triggered directly by oxidative stress. In the present study, we evaluated whether the antioxidant resin from Virola oleifera (RV) could attenuate renal damage in an experimental mouse model of CIN. Adult male Swiss mice were divided into six groups and pre-treated orally with RV (10, 100 and 300 mg/kg), N-acetylcysteine (200 mg/kg) or vehicle for 5 days before the induction of CIN and Control group. Renal function was assessed by measuring plasma creatinine and urea levels. Additionally, renal oxidative stress and apoptosis/cell viability were determined with flow cytometry. Finally, kidney tissues were sectioned for histopathological examination. In this CIN model, pre-treatment with RV improved renal function, lowered the mortality rate, and reduced oxidative stress and apoptosis in both the medulla and cortex renal cells in a dose-dependent manner. Moreover, the RV treatment had beneficial effects on kidney histopathology that were superior to the standard treatment with N-acetylcysteine. These data suggest that because of its antioxidative and antiapoptotic effects and its ability to preserve renal function, resin from Virola oleifera may have potential as a new therapeutic approach for preventing CIN.
- Subjects
KIDNEY disease treatments; VIROLA (Genus); GUMS &; resins; LABORATORY mice; OXIDATIVE stress; KIDNEY tubules
- Publication
PLoS ONE, 2015, Vol 10, Issue 12, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0144329