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- Title
Effect of Topical Betaxolol on the Acute Rise of Aqueous Flare Induced by Highly Selective Agonists for Prostaglandin E<sub>2</sub> Receptor Subtypes in Pigmented Rabbits.
- Authors
Yanagisawa, Shuichiro; Hayasaka, Seiji; Zhang, Xue-Yun; Hayasaka, Yoriko; Nagaki, Yasunori; Kitagawa, Kiyotaka
- Abstract
Purpose: To evaluate the role of topical betaxolol on experimental ocular inflammation in rabbits. Method: Transcorneal diffusion of highly selective agonists for prostaglandin E2 receptor subtypes (EP), 25 μg/ml, with the use of a glass cylinder, was performed to produce aqueous flare elevation in pigmented rabbits. Betaxolol was topically administered before EP agonist application. Aqueous flare was measured with a laser flare cell meter. Results: Performing topical instillation of 0.5% betaxolol 4 times inhibited 52 ± 9% of EP2-agonist (ONO-AE1-259-01)-induced aqueous flare elevation. The inhibition of flare elevation was dependent on the number of betaxolol instillations. Betaxolol did not suppress the elevation induced by an EP4 agonist (ONO-AE1-392). Conclusion: Betaxolol inhibited EP2-agonist-induced aqueous flare elevation in pigmented rabbits. Copyright © 2002 S. Karger AG, Basel
- Publication
Ophthalmic Research, 2002, Vol 34, Issue 1, p48
- ISSN
0030-3747
- Publication type
Article
- DOI
10.1159/000048325