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- Title
Measuring and Modelling the Epithelial- Mesenchymal Hybrid State in Cancer: Clinical Implications.
- Authors
Jolly, Mohit Kumar; Murphy, Ryan J.; Bhatia, Sugandha; Whitfield, Holly J.; Redfern, Andrew; Davis, Melissa J.; Thompson, Erik W.
- Abstract
The epithelial-mesenchymal (E/M) hybrid state has emerged as an important mediator of elements of cancer progression, facilitated by epithelial mesenchymal plasticity (EMP). We review here evidence for the presence, prognostic significance, and therapeutic potential of the E/M hybrid state in carcinoma. We further assess modelling predictions and validation studies to demonstrate stabilised E/M hybrid states along the spectrum of EMP, as well as computational approaches for characterising and quantifying EMP phenotypes, with particular attention to the emerging realm of single-cell approaches through RNA sequencing and protein-based techniques.
- Subjects
RNA sequencing; CANCER invasiveness; COMPUTATIONAL biology; EPITHELIAL-mesenchymal transition; MODEL validation; PHENOTYPES
- Publication
Cells Tissues Organs, 2022, Vol 211, Issue 2, p110
- ISSN
1422-6405
- Publication type
Article
- DOI
10.1159/000515289