We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Synthesis and neurotropic activity of 6-thio-substituted pyrano[3,4- c]pyridine and 1-aminopyrano[4,3- d]-thieno[2,3- b]pyridine derivatives and 9-substituted pyrido[2,3- b]thieno[3,2- d]pyrimidines.
- Authors
Paronikyan, E. G.; Akopyan, Sh. F.; Noravyan, A. S.; Dzhagatspanyan, I. A.; Nazaryan, I. M.; Akopyan, A. G.
- Abstract
Methods for the synthesis of condensed thieno[3,2- d]pyrimidines based on 3,3-dimethyl-8-morpholino-6thioxo-3,4,6,7-tetrahydro-1H-pyrano[3,4- c]pyridine-5-yl cyanide have been developed. The neurotropic properties of the synthesized compounds have been investigated. Compounds possessing anticonvulsant activity and sedative properties are found. These compounds also exhibit an activating effect that makes them analogous to the well-known drug diazepam.
- Subjects
PYRIMIDINES; HETEROCYCLIC compounds; CYANIDES; NEUROPHARMACOLOGY; PYRIDINE; DIAZEPAM
- Publication
Pharmaceutical Chemistry Journal, 2010, Vol 44, Issue 4, p183
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-010-0426-5