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- Title
Neurological Manifestations Associated with Parvovirus B19 Infection in Immunocompetent Children: Case Series and Systematic Review.
- Authors
Monteiro, Vinícius Silva; Baía-da-Silva, Djane Clarys; Silva, Valderjane Aprigio; João, Guilherme Augusto Pivoto; Marinho, Eveny Perlize Melo; Cubas-Vega, Nadia Carolina; Val, Fernando Fonseca Almeida; Perez-Gomez, Aline Stephanie; Monte, Rossiclea Lins; Mota, Adolfo; Lacerda, Marcus Vinícius Guimarães; Bastos, Michele Souza; Pivoto João, Guilherme Augusto; Souza Bastos, Michele
- Abstract
An increasing number of reports have described human parvovirus B19 infection in association with a variety of neurological manifestations, especially in children. This study assessed the clinical and laboratory outcomes found in a case series of immunocompetent children who tested positive for parvovirus B19 by qualitative polymerase chain reaction assays of cerebrospinal fluid, in a tertiary referral center in the western Brazilian Amazon. We screened 178 children with clinically diagnosed central nervous system infections (meningoencephalitis). Of these, five (2.8%) were positive for parvovirus B19. A literature review also presented herein identified a further 50 cases of parvovirus B19 with neurological manifestations. Thus, even if the classic signs of parvovirus B19 infection are absent, such as the well-known rash, children with signs of neurological infection should also be evaluated for parvovirus B19 infection.
- Subjects
PARVOVIRUS diseases; RESEARCH; VIRUSES; NEUROLOGICAL disorders; RESEARCH methodology; MEDICAL cooperation; EVALUATION research; COMPARATIVE studies; RESEARCH funding; POLYMERASE chain reaction; FIFTH disease; DISEASE complications
- Publication
Journal of Tropical Pediatrics, 2021, Vol 67, Issue 4, p1
- ISSN
0142-6338
- Publication type
journal article
- DOI
10.1093/tropej/fmab078