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- Title
A Randomized Controlled Trial on Safety and Efficacy of Single Intramuscular versus Staggered Oral Dose of 600 000IU Vitamin D in Treatment of Nutritional Rickets.
- Authors
Mondal, Krishanu; Seth, Anju; Marwaha, Raman K.; Dhanwal, Dinesh; Aneja, Satinder; Singh, Ritu; Sonkar, Pitambar
- Abstract
Objective: Comparison of efficacy and safety of two different regimens of vitamin D—600 000 IU as a single intramuscular dose, and 60 000IU orally once a week for 10 weeks—in treatment of nutritional rickets.Methods: Children with nutritional rickets (age: 0.5–5 years, n = 61) were randomized to receive either 60 000IU vitamin D orally once a week for 10 weeks or 600 000IU single intramuscular injection. Serum calcium, phosphate, alkaline phosphatase, urinary calcium/creatinine ratio, serum 25 hydroxy vitamin D and radiological score were compared at 12-week follow-up.Results: No difference was found in efficacy of the two regimens on comparing biochemical and radiological parameters. Serum 25 hydroxy vitamin D >100 ng/ml was found in two children in the oral group and one child in the intramuscular group. No child developed hypercalcemia or hypercalciuria after starting treatment.Conclusion: Staggered oral and one-time intramuscular administrations of 600 000IU vitamin D are equally effective and safe in treatment of nutritional rickets.
- Subjects
RANDOMIZED controlled trials; INTRAMUSCULAR injections; VITAMIN D; RICKETS; SERUM; CALCIUM phosphate
- Publication
Journal of Tropical Pediatrics, 2014, Vol 60, Issue 3, p203
- ISSN
0142-6338
- Publication type
Article
- DOI
10.1093/tropej/fmt105