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- Title
Isoniazid associated psychosis: case series from a tertiary care centre.
- Authors
Singh, Hemendra; H. J., Gayathri Devi; Chabaria, Mamatha; Shekar, Kartik
- Abstract
Isoniazid (INH) is a commonly used first line antitubercular drug. INH associated psychosis is a rare psychiatric manifestation. We report two cases of pulmonary tuberculosis, where the patients developed psychosis after being given a therapeutic dose of INH. In vulnerable patients, INH may cause change in concentration of neurotransmitters by inhibition of monoamine oxidase (MAO) and deficiency of pyridoxine. This might precipitate psychosis. Our observation also supports the hypothesis that INH associated psychotic disorders might have a pathophysiological substrate in common with some schizophrenia patients, who show remarkable response to low doses of atypical antipsychotic agents and pyridoxine supplementation.
- Subjects
ISONIAZID; PSYCHOSES; TERTIARY care
- Publication
Open Journal of Psychiatry & Allied Sciences, 2018, Vol 9, Issue 2, p161
- ISSN
2394-2053
- Publication type
Case Study
- DOI
10.5958/2394-2061.2018.00019.8