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- Title
Neutrophil-Lymphocyte Ratio Predicts Medium-Term Survival Following Elective Major Vascular Surgery: A Cross-Sectional Study.
- Authors
Bhutta, Hina; Agha, Riaz; Wong, Joy; Tang, Tjun Y.; Wilson, Yvonne G.; Walsh, Stewart R.
- Abstract
Background: The systemic nature of atherosclerosis compromises medium-term survival following major vascular surgery. Neutrophil—lymphocyte ratio (NLR) is a simple index of systemic inflammatory burden which correlates with survival following percutaneous coronary intervention. Methods: Patients undergoing elective major vascular surgery in 2 tertiary vascular units were identified from prospectively maintained databases. Factors associated with 2-year mortality were assessed by univariate and multivariate analyses. Results: Over a 4-year period, 1021 patients underwent elective major vascular surgery (carotid endarterectomy, abdominal aortic aneurysm repair, lower limb revascularization). Two-year mortality was 11.2%. In multivariate analysis, preoperative NLR > 5 was independently associated with 2-year mortality (multivariate odds ratio [OR] 2.21; 95% confidence interval [CI] 1.22-4.01). Conclusion: Preoperative NLR identifies patients at increased risk of death within 2 years of major vascular surgery. This simple index may facilitate targeted preventive measures for high-risk patients.
- Subjects
ENGLAND; PREVENTION of surgical complications; ACADEMIC medical centers; ANALYSIS of variance; VASCULAR surgery; COMPUTER software; CONFIDENCE intervals; REPORTING of diseases; EPIDEMIOLOGY; LONGITUDINAL method; LYMPHOCYTES; MULTIVARIATE analysis; NEUTROPHILS; HEALTH outcome assessment; REGRESSION analysis; STATISTICS; SURVIVAL analysis (Biometry); LOGISTIC regression analysis; CYTOMETRY; DATA analysis; TREATMENT effectiveness; CROSS-sectional method; RECEIVER operating characteristic curves
- Publication
Vascular & Endovascular Surgery, 2011, Vol 45, Issue 3, p227
- ISSN
1538-5744
- Publication type
Article
- DOI
10.1177/1538574410396590