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- Title
Biologically Active Symmetric and Asymmetric Dicationic Bis(isatin hydrazones): What is Better―To Complicate or Simplify the Spacer?
- Authors
Bogdanov, A. V.; Voloshina, A. D.; Amerkhanova, S. K.; Tsivileva, O. M.; Rakhmatullin, R. R.; Mironov, V. F.
- Abstract
The reaction of bisisatins containing a 1,ω-alkylene, -arylene, or -alkyluracil spacer with ammonium acetohydrazides gave a series of symmetric and asymmetric dicationic isatin-3-acylhydrazones. It was shown that the antimicrobial activity of the new compounds depends on the structure of the spacer and the nature of the substituent in the aromatic fragment. 5-Substituted isatin derivatives, where the heterocyclic fragments are linked by an 9- and 10-carbon alkylene chains, exhibit bactericidal effect against resistant strains of S. aureus at the level of Norfloxacin and the fungal pathogen P. cactorum, which causes plant late blight.
- Subjects
ISATIN; ANTI-infective agents; NORFLOXACIN; CYTOTOXINS; AMMONIUM
- Publication
Russian Journal of Organic Chemistry, 2023, Vol 59, Issue 11, p1831
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S1070428023110015