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- Title
Synthesis and In Vitro Anticancer Activity of Triazolyl Analogs of Podophyllotoxin, a Naturally Occurring Lignin.
- Authors
Ganaie, B. A.; Banday, J. A.; Bhat, B. A.; Ara, T.
- Abstract
A series of triazolyl-modified podophyllotoxin analogs have been designed and synthesized by utilizing Huisgen 1,3-dipolar cycloaddition in order to develop potent antitumor agents. The synthesized analogs were assessed for in vitro anticancer activity against four human cancer cell lines, including MDA-MB-231 and MCF-7 (human breast cancer cells), A549 (human lung cancer), PC3 (human prostate cancer), and non-tumor human breast epithelial cell line FR2 by using MTT assay. Some of the tested derivatives exhibited potent biological profiles in comparison to podophyllotoxin. p-Nitrophenyltriazolyl and p-hydroxyphenyltriazolyl analogs were found to be the most potent with IC50 values of 19.0 (against PC3 cell line and 20.0 mM (against A549 cell line), respectively.
- Subjects
ANTINEOPLASTIC agents; PODOPHYLLOTOXIN; CELL lines; CANCER cells; LUNG cancer
- Publication
Russian Journal of Organic Chemistry, 2021, Vol 57, Issue 12, p2039
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S1070428021120216