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- Title
Research status on Ts-SV40-mediated temperature sensitive cells.
- Authors
LIAO Yuping; LI Xiaohong; SUN Hongtao
- Abstract
The in vitro passage number and proliferation of non-immortalized cells are limited, which restrictions cell therapy or in vitro studies. Cells transfected with temperature sensitive simian virus 40 large T antigen (ts-SV40LT) gene could show the greatest proliferation. The cells can be amplified with compensating the lack of limited number of cells under the permissive temperature. Non-permissive temperature can be used in studying the cell therapy or its other physiological characteristics. This research field involves peritoneal stromal cells, satellite cells of urinary tract, oral epithelial cells, adrenal medullary cells, bone marrow-derived endothelial cells, retinal progenitor cells, mesenchymal stem cells, hematopoietic stem cells, mast cells, podocytes and Kupffer cells. In this study, the current research on Ts-SV40-mediated temperature-sensitive cells was reviewed.
- Subjects
HYPOTHERMIA; CELLULAR therapy; MESENCHYMAL stem cells; KUPFFER cells; SATELLITE cells
- Publication
Tianjin Medical Journal, 2015, Vol 43, Issue 3, p323
- ISSN
0253-9896
- Publication type
Article
- DOI
10.11958/j.issn.0253-9896.2015.03.027