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- Title
Synthesis of 3-substitued 5-(2-thienyl)isoxazoles.
- Authors
Potkin, V. I.; Petkevich, S. K.; Kurman, P. V.
- Abstract
The reaction of 3,4,4-trichloro-1-(2-thienyl)but-3-en-1-one with hydroxylamine gave 3-hydroxyiminomethyl-5-(2-thienyl)isoxazole which was converted into 5-(2-thienyl)isoxazole-3-carbonitrile by the action of acetic anhydride in pyridine. 5-(2-Thienyl)isoxazole-3-carbonitrile reacted with hydroxylamine to produce the corresponding amide oxime. Heterocyclization of its O-acyl derivatives in acetic acid afforded 5-substituted 3-[5-(2-thienyl)isoxazol-3-yl]-1,2,4-oxadiazoles.
- Subjects
CHEMICAL reactions; PHYSICAL organic chemistry; THIOPHENES; KETONIC acids; ORGANIC compounds
- Publication
Russian Journal of Organic Chemistry, 2011, Vol 47, Issue 6, p928
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S1070428011060169