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- Title
Association between Vitamin D3 and infl ammatory bowel diseases.
- Authors
Babur, Waseem; Rauf, Muhammad; Mahmood, Tariq; Altaf, Anam
- Abstract
Objective: To fi nd out the association between vitamin D3 and infl ammatory bowel disease Study design: Randomized Controlled Trail Place and duration: Th e study was conducted in King Salman Armed Forces Hospital, Tabuk, Kingdom of Saudi Arabia for the time period of 1 years (July 2015-July 2016). Material & Methods: Th e study was a randomized controlled trail with 1:1 ratio of two groups. Th e sample size of 50 patients was achieved. Th e interventional group was provided with 300,000 IU intramuscular vitamin-D while the placebo group is given 1ml of saline and followed for 4 months. Both the groups were measured for PTH, ESR and serum level of 25 (OH)- vitamin D3 before and aft er intervention. Chi square test was performed to observe the association between vitamin D3 and infl ammatory bowel disease (IBD). Results: Total 50 patients were observed 25 in placebo group and 25 in intervention group. Th e study found out that serum hydroxyl vitamin D3 level in interventional group before and aft er was 32.3±0.67, 41.7±6.2 while in placebo group it was 33.9±8.9 and 34.8±9.6 respectively 95% confi dence interval. Conclusion: Higher level of vitamin D3 is associated with prevention of infl ammatory bowel diseases. Vitamin-D is playing a role of immune regulator in body and tends to improve bone and calcium homeostasis.
- Subjects
INFLAMMATORY bowel disease treatment; CHOLECALCIFEROL; DISEASE duration; BLOOD sedimentation; PARATHYROID hormone; RANDOMIZED controlled trials; THERAPEUTICS
- Publication
Pakistan Journal of Surgery, 2017, Vol 33, Issue 4, p246
- ISSN
0258-8552
- Publication type
Article