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- Title
Clinicopathological Study of Two Subtypes of Picks Disease in Japan.
- Authors
T. Odawara; E. Iseki; A. Kanai; T. Arai; T. Katsuragi; H. Hino; Y. Furukawa; M. Kato; T. Yamamoto; K. Kosaka
- Abstract
AbstractWe examined the clinical and neuropathological findings in 3 cases of Picks disease with Pick bodies (PiD) and 7 cases of atypical Picks disease without Pick bodies (aPiD). PiD and aPiD cases corresponded clinically to frontotemporal dementia and semantic dementia, respectively, based on the clinical diagnostic criteria of frontotemporal lobar degeneration. Brain CT showed that cerebral atrophy was accentuated at an early stage of the illness in the anterior portion of the frontal lobes in PiD cases and in the anterior portion of the temporal lobes in aPiD cases. Neuropathologically, PiD cases showed more circumscribed lobar atrophy than aPiD cases. Both PiD and aPiD cases revealed moderate to severe degeneration with neuronal loss and gliosis in the affected cerebral cortex and subcortical nuclei, but only aPiD cases had pyramidal tract degeneration. Immunohistochemical analyses demonstrated that tauopathy with phosphorylated tau accumulation in the Pick bodies in PiD cases, while aPiD cases showed ubiquitinopathy with ubiquitin accumulation in the intraneuronal and dendritic inclusions. These findings suggested that two subtypes of Picks disease in Japan can be distinguished not only neuropathologically but also clinically based on differences in pathogenesis.Copyright © 2003 S. Karger AG, Basel
- Subjects
NEUROLOGICAL disorders; DEMENTIA; PRESENILE dementia; BRAIN; TEMPORAL lobe
- Publication
Dementia & Geriatric Cognitive Disorders, 2003, Vol 15, Issue 1, p19
- ISSN
1420-8008
- Publication type
Article
- DOI
10.1159/000066674