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- Title
Limited value of KAI1/CD82 protein expression as a prognostic marker in human gastric cancer.
- Authors
Knoener, Maximilian; Krech, Till; Puls, Florian; Lehmann, Ulrich; Kreipe, Hans; Christgen, Matthias
- Abstract
The cell surface glycoprotein KAI1/CD82 suppresses tumor growth and metastasis in animal models. This study aimed to evaluate the prognostic relevance of KAI1/CD82 protein expression in human gastric cancer. Primary gastric carcinomas (n=271) with a mean clinical follow-up time of 48 months were immunostained using the monoclonal anti{-}KAI1/CD82 antibody G2. Staining was evaluated as negative versus positive for statistical analysis. KAI1/CD82 immunoreactivity was absent in 103/271 (38%) cases. There was a trend towards KAI1/CD82 negativity in poorly differentiated cases (p=0.0679). Moreover, KAI1/CD82-negative carcinomas were associated with a higher pT status (p=0.0222), metastatic lymph node involvement (p=0.0018) and a higher clinical tumor stage (p=0.0050). The median overall survival times of KAI1/CD82-negative and KAI1/CD82-positive gastric carcinomas were 20 and 37 months, respectively (p=0.2305). These results are in line with the proposed function of KAI1/CD82 as a suppressor of tumor growth and metastasis. However, these data suggest that KAI1/CD82, as detected by immunohistochemistry, is of limited value as a prognostic marker for gastric cancer in routine histological workup.
- Subjects
STOMACH cancer; BIOMARKERS; MEMBRANE glycoproteins; METASTASIS; GENE expression; FOLLOW-up studies (Medicine); IMMUNOHISTOCHEMISTRY; GLYCOPROTEINS
- Publication
Disease Markers, 2012, Vol 32, Issue 6, p337
- ISSN
0278-0240
- Publication type
Article
- DOI
10.1155/2012/737132