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- Title
Percutaneous CT-Guided Bone Lesion Biopsy for Confirmation of Bone Metastases in Patients with Breast Cancer.
- Authors
Kovacevic, Lucija; Cavka, Mislav; Marusic, Zlatko; Kresic, Elvira; Stajduhar, Andrija; Grbanovic, Lora; Dumic-Cule, Ivo; Prutki, Maja
- Abstract
We aimed to determine diagnostic accuracy of CT-guided bone lesion biopsy for the confirmation of bone metastases in patients with breast cancer and assessment of hormone receptor status in metastatic tissue. A total of 56 female patients with breast cancer that underwent CT-guided biopsy of suspected bone metastasis were enrolled in this retrospective study. Three different techniques were employed to obtain samples from various sites of skeleton. Collectively, 11 true negative and 3 false negative findings were revealed. The sensitivity of CT-guided biopsy for diagnosing bone metastases was 93.6%, specificity was 100% and accuracy was 94.8%. Discordance in progesterone receptor status and complete concordance in estrogen receptor status was observed. Based on our single-center experience, bone metastasis biopsy should be routinely performed in patients with breast cancer and suspicious bone lesions, due to the impact on further treatment.
- Subjects
BONE metastasis; CALCIFICATIONS of the breast; HORMONE receptor positive breast cancer; PROGESTERONE receptors; HORMONE receptors; BIOPSY; SENTINEL lymph nodes; BONE cancer
- Publication
Diagnostics (2075-4418), 2022, Vol 12, Issue 9, pN.PAG
- ISSN
2075-4418
- Publication type
Article
- DOI
10.3390/diagnostics12092094