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- Title
In vivo long-term effects of retinoic acid exposure in utero on induced hyperplastic epidermal foci in murine skin.
- Authors
García-Fernández, Rosa A.; Pérez-Martínez, Claudia; Espinosa-Álvarez, Javier; García-Iglesias, Maria J.
- Abstract
Adult Naval Medical Research Institute (NMRI) mice, after prenatal exposure to retinoic acid (RA), were treated with a standard two-stage skin carcinogenesis regime to characterize hyperplastic epidermal foci that precede the appearance of cutaneous papillomas, and to investigate the in vivo long-term action of RA on adult mouse skin treated with DMBA (7,12 dimethyl benz[a]anthracene) and TPA (12-O-tetradecanoylphorbol 13-acetate). The results demonstrate that RA administered to pregnant mice had a long-term inhibitory action on the cell differentiation and development of hyperplastic lesions occurring prior to cancer on the adult skin of their offspring as well as a stimulatory effect on cell proliferation of these hyperplastic lesions.
- Subjects
TRETINOIN; DRUG efficacy; VETERINARY medicine; SKIN cancer; HYPERPLASIA; CELL proliferation; LABORATORY mice
- Publication
Veterinary Dermatology, 2007, Vol 18, Issue 5, p287
- ISSN
0959-4493
- Publication type
Article
- DOI
10.1111/j.1365-3164.2007.00607.x