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- Title
Detection of α-papillomaviruses in extragenital cutaneous squamous cell carcinomas.
- Authors
Weiss, Morgane; Ferré, Valentine M; Deschamps, Lydia; Evrard, Diane; Gonthier, Clémentine; Charpentier, Charlotte; Brunet-Possenti, Florence
- Abstract
This article discusses two cases of patients with HIV who developed cutaneous squamous cell carcinomas (cSCCs) that tested positive for alpha (α)-papillomaviruses (HPVs). The patients had a history of recurrent cervical intraepithelial neoplasia (CIN) and persistent anogenital HPV infections. The study suggests that defective immunity towards α-HPVs may also occur in the skin and lead to cSCC. The detection of high-risk (HR)-HPVs in cSCC could indicate hypersusceptibility to HPV infection and may impact therapeutic strategies for cSCC.
- Subjects
SQUAMOUS cell carcinoma; SKIN cancer; NUCLEOTIDE sequencing; BOWEN'S disease
- Publication
British Journal of Dermatology, 2024, Vol 190, Issue 5, p762
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1093/bjd/ljae047