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- Title
Somatic Genomic Mosaicism in Multiple Myeloma.
- Authors
Ye, Christine J.; Chen, Jason; Liu, Guo; Heng, Henry H.
- Abstract
Keywords: cellular heterogeneity; fuzzy inheritance; genome chaos; genome theory; macro-cellular evolution; two phases of cancer evolution; karyotype coding; system inheritance EN cellular heterogeneity fuzzy inheritance genome chaos genome theory macro-cellular evolution two phases of cancer evolution karyotype coding system inheritance 1 5 5 04/24/20 20200422 NES 200422 Background Somatic genomic mosaicism occurs when somatic cells of the body display different genotypes (Table 1), it has recently received increased attention because of its implications in disease, including neurodegenerative diseases and Down syndrome (Iourov et al., [24], [25], [26]; Biesecker and Spinner, [5]; Hultén et al., [23]; Vijg, [45]; Campbell et al., [8]; Fernández et al., [12]). Here, "somatic mosaicism" rather than "genomic heterogeneity" is used to promote the exchangeable use of these two terms in cancer research.</td></tr><tr><td valign="top" align="left"><bold>Karyotype coding vs. gene coding</bold><break /> Karyotype coding is responsible for passing system inheritance, while gene coding determines parts inheritance (Ye et al., <xref ref-type="bibr" rid="bibr51">2019b</xref>). The two-phased cancer evolution pattern also challenges the general assumption that the accumulation of microevolution over time leads to macroevolution (Heng, <xref ref-type="bibr" rid="bibr18">2015</xref>, <xref ref-type="bibr" rid="bibr19">2019</xref>).</td></tr><tr><td valign="top" align="left"><bold>Genome chaos vs. chromothripsis</bold><break /> Genome chaos or karyotype chaos refers to a phenomenon of rapid and massive genome re-organization. Cellular heterogeneity, fuzzy inheritance, genome chaos, genome theory, macro-cellular evolution, two phases of cancer evolution, karyotype coding, system inheritance.
- Subjects
MOSAICISM; MULTIPLE myeloma; SOMATIC mutation; IMMUNOGLOBULIN class switching; KARYOTYPES; GENETIC mutation; BIOLOGICAL systems; GENOTYPE-environment interaction
- Publication
Frontiers in Genetics, 2020, Vol 11, p1
- ISSN
1664-8021
- Publication type
Article
- DOI
10.3389/fgene.2020.00388