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- Title
Epstein-Barr virus-associated, CD20-polyclonal lymphoproliferative disorder after matched unrelated donor marrow transplantation.
- Authors
Anderlini, P.; Valbuena, J. R.; Champlin, R. E.; Bueso-Ramos, C. E.
- Abstract
The article provides information on the post-transplant lymphoproliferative disorder (PTLD), which is a well-recognized complication of allogeneic stem cell transplantation, with a cumulative incidence of 1% at 10 years. PTLDs occurring in the first 6-12 months after stern cell transplant usually manifest as clinically aggressive B-cell lymphomas of donor origin, and the majority of these cases are believed to express the B-cell-associated CD20 surface antigen, although only scarce data have been reported. Most of these cases are associated with the Epstein-Barr virus. Known risk factors for the development of early-onset PTLD include T-cell depletion of the gall, matched unrelated donor or mismatched related donor transplant, antithymocyte globulin therapy for prophylaxis or treatment of graft-versus-host disease, and anti-CD3 monoclonal antibody therapy.
- Subjects
LYMPHOPROLIFERATIVE disorders; EPSTEIN-Barr virus; LYMPHATIC diseases; CELL proliferation; BONE marrow; TRANSPLANTATION of organs, tissues, etc.
- Publication
Bone Marrow Transplantation, 2004, Vol 34, Issue 10, p919
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1704683