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- Title
Serum soluble urokinase-type plasminogen activator receptor as a serum marker of inflammatory response that leads to tissue damage and surgical complication.
- Authors
Tognoli, Emiliano; Luigi Giuseppe Leoni, Matteo; Morelli, Daniele; Sottotetti, Elisa; Martinetti, Antonia; Signoroni, Stefano; Galeone, Carlotta; Gallino, Gianfranco
- Abstract
ABSTRACT Unrestrained activation of the proteolytic systems in anastomotic tissue during repair has been implicated in the pathogenesis of anastomotic leakage. We hypothesized that this mechanism may promote an up-regulation of the urokinase-type plasminogen activator system and a spillover of soluble urokinase-type plasminogen activator receptor (suPAR) into blood. In this retrospective analysis patients with anastomotic leakage were compared with a group of matched uncomplicated patients. Anastomotic leakage complicated patients had significantly higher suPAR ( p = 0.04) levels until day 3 after surgery. The area under the receiver-operating characteristic (ROC) for suPAR was higher than that CRP (0.874 vs. 0.836). Their analysis suggests the possible use of suPAR as serum marker to characterize the persistent inflammatory response that lead to tissue damage and surgical complication.
- Subjects
ITALY; ANALYSIS of variance; BIOMARKERS; C-reactive protein; CANCER treatment; CELL receptors; COMPARATIVE studies; DIGESTIVE organ surgery; DYNAMICS; EXTRACELLULAR space; INFLAMMATION; PATIENTS; POSTOPERATIVE period; PROBABILITY theory; STATISTICAL hypothesis testing; SURGERY; SURGICAL complications; UROKINASE; WOUND healing; SECONDARY analysis; SPECIALTY hospitals; REPEATED measures design; RETROSPECTIVE studies; RECEIVER operating characteristic curves; SURGICAL anastomosis; DATA analysis software; BLOOD
- Publication
Wound Repair & Regeneration, 2016, Vol 24, Issue 6, p1036
- ISSN
1067-1927
- Publication type
Article
- DOI
10.1111/wrr.12493