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- Title
Oxidative Kinetic Resolution of Secondary Alcohols with Salen-Mn(III)/NBS/NaClO System.
- Authors
Zhang, Yuecheng; Gao, Baosheng; Zhou, Qiao; Zhao, Jiquan
- Abstract
The oxidative kinetic resolution of racemic secondary alcohols was efficiently catalyzed by a chiral Mn(III)-salen complex using sodium hypochlorite (NaClO) as an oxidant in the presence of 8 mol% N-bromosuccinimide (NBS) in a dichloromethylene-water mixture solvent at room temperature. Excellent ee's (up to 99 %) of chiral secondary alcohols were achieved in most cases. Graphical Abstract: [Figure not available: see fulltext.]Chiral Mn(III)-salen complex catalyzed oxidative kinetic resolution (OKR) of secondary alcohols has been achieved with sodium hypochlorite as an oxidant in the presence of a catalytic amount of N-bromosuccinimide. This novel protocol is very efficient for the OKR of a variety of secondary alcohols.
- Subjects
KINETIC resolution; ALCOHOL; OXIDATION; MANGANESE; SODIUM hypochlorite; BROMOSUCCINIMIDE
- Publication
Catalysis Letters, 2014, Vol 144, Issue 11, p1797
- ISSN
1011-372X
- Publication type
Article
- DOI
10.1007/s10562-014-1339-9