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- Title
Sentinel Lymph Node Biopsy in Breast Cancer.
- Authors
Lauridsen, Mette Cathrine; Garne, Jens Peter; Sørensen, Flemming Brandt; Melsen, Flemming; Lernevall, Anders; Christiansen, Peer
- Abstract
One hundred and twenty-four patients with palpable tumours underwent sentinel lymph node biopsy (SLNB) and subsequent axillary lymph node dissection. Ultrasound of the axilla was used as part of the diagnostic work-up on all patients and those with lymph node metastasis verified by fine-needle aspiration biopsy (FNAB) were not included. For identifying the SLNs, a combination of Tc-99m-labelled human albumin (Solco-ALBU-RES) and blue dye (Patent Blue V) was used. No lymphoscintigraphy was performed. The SLN was successfully identified in 122 out of 124 (98%) patients and 66 (54%) patients were found to have metastatic involvement of the axillary lymph nodes. In 52 (79%) of these patients, the SLNs were the only nodes involved, 28 (54%) had micrometastasis only. The false-negative rate was 1.5%. This method has proven valid in the staging of the axilla in patients with breast cancer. The advanced techniques of serial sectioning and immunohistochemical staining further improve the diagnostic advantage offered by the SLNB, as it increases the possibility of diagnosing micrometastatic deposits.
- Subjects
LYMPH nodes; BIOPSY; BREAST cancer; DYES in medical diagnosis; RADIOACTIVE tracers in histology; HISTOPATHOLOGY
- Publication
Acta Oncologica, 2004, Vol 43, Issue 1, p20
- ISSN
0284-186X
- Publication type
Article
- DOI
10.1080/02841860310017757