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- Title
T helper 17 cells: A new actor on the stage of type 2 diabetes and aging?
- Authors
Chang, Yi‐Cheng; Hee, Siow‐Wey; Chuang, Lee‐Ming
- Abstract
The discovery of new T helper cell subsets, including T regulatory cells (Tregs) and Th17 cells resolved many previously unexplained phenomena5. Metformin improves mitochondrial function and enhances autophagy of T helper 17 cells, leading to decreased inflammation. For example, uncontrolled Th2 cell responses induce asthma2, and abnormal Th1 cells responses contribute to the pathogenesis of psoriasis3 and inflammatory bowel disease4. Tregs also induce apoptosis of effector cells, directly interact with dendritic cells to suppress immune reaction and suppress effector T cells through interaction with cytotoxic T lymphocyte-associated protein 46,7.
- Subjects
T helper cells; TYPE 2 diabetes; ANGIOTENSIN II; REGULATORY T cells; STAGE actors &; actresses; LIVER cells
- Publication
Journal of Diabetes Investigation, 2021, Vol 12, Issue 6, p909
- ISSN
2040-1116
- Publication type
Article
- DOI
10.1111/jdi.13541