We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
T-Cell Colony Formation in Healthy Homosexual Men without Anti-Human Immunodeficiency Virus Antibody.
- Authors
Wakabayashi, Yoshihisa; Sugimoto, Masakuni; Ishiyama, Taijiro; Hashimoto, Manabu; Horie, Seiichi; Hirose, Shun-ichi
- Abstract
In order to study the abnormal differentiation and proliferation of precursor T cells in homosexual men, a study was made of T-cell colony formation in 15 healthy homosexual men without anti-human immunodeficiency virus (HIV) antibody. The colony forming method used was the one-step monolayer technique using phytohemagglutinin as an inducer. Our results revealed that colony formation was extremely reduced and 3 cases showed no colony growth. However, with the addition of recombinant interleukin 2 to the culture system, the number of colonies increased up to the same level as in heterosexual controls. In addition, the analysis of CD3+, 4+, and 8+ cells of colony component cells revealed a decrease in CD3+ and 4+ cells. However, with the addition of recombinant interleukin 2, the numbers of CD3+ cells distinctly increased. The above results suggest that a disorder in the differentiation and proliferation of precursor T cells in homosexual men might be one of the causes of immunodeficiency. Copyright © 1989 S. Karger AG, Basel
- Publication
Acta Haematologica, 1989, Vol 82, Issue 4, p187
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000205374