We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Current Concepts of Abnormal Stem Cell Proliferation in Human Disease.
- Authors
Robinson, William A.
- Abstract
Using acute myeloid leukemia as an example, the concept of abnormal hematopoietic stem cell production has been examined. It is concluded that the major problem does not lie in humoral regulators, either stimulators or inhibitors, of stem cell production but in intrinsic cellular defects which do not allow cells to respond to these materials. The nature of the stem cell defects has not been defined. Similar mechanisms appear to exist in other human hematopoietic disorders in which abnormal stem cell proliferation is a major feature. Copyright © 1979 S. Karger AG, Basel
- Publication
Acta Haematologica, 1979, Vol 62, Issue 5/6, p331
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000207598