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- Title
Methotrexate and Citrovorum Factor after Histoincompatible Allogeneic Bone Marrow Transplants in Dogs.
- Authors
Gratwohl, Alois A.; Bull, Malcolm I.; Graw, jr., Robert G.; Norton, Larry; Knutsen, Turid
- Abstract
Methotrexate (MTX) followed by citrovorum factor (CVF) rescue was evaluated for its effectiveness in reducing graft-versus-host disease (GVHD) in lethally irradiated dogs transplanted with bone marrow from unrelated histoincompatible donors. Animals were given no immunosuppressive therapy (group A) or a combined regimen of MTX and CVF (group AMC). These two groups were compared with a group of animals transplanted earlier given MTX alone (group AM). Animals in the AMC group lived significantly longer than the A group (p < 0.05). Engraftment rate, hematopoietic recovery and incidence of GVHD were similar in all three groups. Incidence of early deaths was significant in the AM group (p < 0.05). It is concluded that MTX combined with CVF increases survival and is an effective posttransplantation immunosuppressive regimen with minimal toxicity. Copyright © 1978 S. Karger AG, Basel
- Publication
Acta Haematologica, 1978, Vol 60, Issue 4, p233
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000207719