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- Title
Effect of a Combination of Citric Acid and Selenium Nanoparticles on Male Rats Nephrotoxicity Caused by Carbon Tetrachloride.
- Authors
Al-Tamimi, Jameel; Ebaid, Hossam; Hassan, Iftekhar; Habila, Mohamed; Al Malahi, Nawal M.; Alhazza, Ibrahim M.
- Abstract
Background: To investigate the therapeutic effects of a combination of citric acid and Se-NPs against carbon tetrachloride (CCl4)-induced renal damage in rats. Methods: Twenty-four rats were divided into three groups (n=8 each). Group 1 (control) received the vehicle, while Group 2 received a single dose of 1 ml/kg CCl4 in liquid paraffin (1:1 volume) via intraperitoneal injection. Group 3 was administered a single dose of 1 ml/kg CCl4 in liquid paraffin and then treated twice a week for three weeks with a dose of 2.5 mg/kg Se-NPs. One-way ANOVA and Tukey's method were used to compare the overall effects of each treatment. Result: CCL4 elevated MDA levels and decreased GSH levels in group 2 animals compared with those in the control group. Se-NPs significantly restored the oxidative stability in group 3. We found that CCL4 significantly increased its effect on renal function, whereas Se-NPs restored the renal structure affected by CCL4. As a result, Se-NPs can potentially reduce the markers of renal injury caused by CCl4, while also restoring oxidative stability and renal structure and function.
- Subjects
CARBON tetrachloride; CITRIC acid; RATS; NEPHROTOXICOLOGY; SELENIUM; NANOPARTICLES; STRUCTURAL stability
- Publication
Indian Journal of Animal Research, 2024, Vol 58, Issue 3, p470
- ISSN
0367-6722
- Publication type
Article
- DOI
10.18805/IJAR.BF-1706