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- Title
Synthesis, characterization, antimicrobial activity and molecular docking study of transition metal complexes based on azo coumarin and thiosemicarbazone derivative.
- Authors
Borhade, Shobha S.; Tryambake, Pravin T.
- Abstract
Mixed ligand metal complexes of Co(II), Fe(III), Cu(II), Zn(II), Cd(II) and Hg(II) metal ions with azo coumarin and thiosemicarbazone derivative have been synthesized. Synthesized ligands were supported by spectroscopic techniques such as IR, 1HNMR, 13CNMR and mass analysis while the structure and probable geometry of metal chelates were explored by FTIR, elemental analysis, molar conductance, mass spectrum, thermogravimetry (TG), and electronic spectra (UV). From thermal studies, activation energy and kinetic parameters (ΔG, ΔH, ΔS) of the complexes were also reported. Synthesized ligands and their metal complexes were studied for antimicrobial potential against various bacterial and fungal pathogens. Further, the antioxidant potential screening was done using 1,1-diphenyl-2-picrylhydrazyl. Synthesized metal complexes displayed modest to excellent antimicrobial potential. The topoisomerase II receptor protein was used for molecular docking of the extraordinary antimicrobial Co and Zn-complex.
- Subjects
SCHIFF bases; THIOSEMICARBAZONES; TRANSITION metal complexes; METAL complexes; MOLECULAR docking; COUMARIN derivatives; ANTI-infective agents; DNA topoisomerase II
- Publication
Journal of the Iranian Chemical Society, 2024, Vol 21, Issue 3, p719
- ISSN
1735-207X
- Publication type
Article
- DOI
10.1007/s13738-023-02953-0