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- Title
MOLECULAR MECHANISMS OF ETOPOSIDE.
- Authors
Montecucco, Alessandra; Zanetta, Francesca; Biamonti, Giuseppe
- Abstract
Etoposide derives from podophyllotoxin, a toxin found in the American Mayapple. It was first synthesized in 1966 and approved for cancer therapy in 1983 by the U.S. Food and Drug Administration (Hande, 1998). Starting from 1980s several studies demonstrated that etoposide targets DNA topoisomerase II activities thus leading to the production of DNA breaks and eliciting a response that affects several aspects of cell metabolisms. In this review we will focus on molecular mechanisms that account for the biological effect of etoposide.
- Subjects
ETOPOSIDE; ANTINEOPLASTIC agents; PODOPHYLLOTOXIN; PODOPHYLLUM peltatum; CANCER treatment
- Publication
EXCLI Journal, 2015, Vol 14, p95
- ISSN
1611-2156
- Publication type
Article
- DOI
10.17179/excli2014-561