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- Title
Prevalence of Aspirin Sensitivity in Patients with Moderate to Severe Asthma According to the Response to 3 Months Asthma Standard Therapy at Allergy and Clinical Immunology Department of Rasool Akram Hospital.
- Authors
Eslami, Narges; Arshi, Saba; Nabavi, Mohammad; Bemanian, Mohammad Hassan; Fallahpour, Morteza; Nojomi, Marzieh; Shokri, Sima; Heris, Javad Ahmadian; Rekabi, Mahsa; Molatef, Rassol; Sedighi, Gholamreza; Darabi, Kian; Torabizadeh, Mehdi; Aghapour, Ali; Ghobadidana, Vahid
- Abstract
Objective: According to most studies, aspirin sensitivity is associated with asthma severity and occasionally poor response to inhaled corticosteroids. The aim of this study was to assess the prevalence of aspirin sensitivity in patients with moderate to severe asthma according to three months standard treatment response. Material and Methods: This randomized clinical trial is done on 18 to 65 years old patients with moderate to severe asthma who referred to the Department of Allergy and Clinical Immunology, Rasool Akram Hospital, since February 2015 to February 2016. To evaluate the patient's response to 3 months asthma standard therapy, prebronchodilator FEV1 values and Asthma Control Test (ACT) scores were assessed before and after the treatment. At the end, patients underwent the oral aspirin challenge test. Results: 65 patients were eligible for the oral aspirin challenge test. The average age of participants was 40.86 ± 11.53 years. 19 males (29.23%) and 46 females (70.77%) were participated. 27 (41.5%) patients were diagnosed with moderate asthma and 38(58.5%) with severe asthma. History reactions to aspirin or NSAID were positive in 18 (27.7%) subjects. The prevalence of aspirin sensitivity was 35.38% based on oral aspirin challenge test. Aspirin sensitivity was more prevalent in patients with moderate asthma (60.9%). Past history of reaction to aspirin or NSAID was significantly associated with positive aspirin challenge test. There were no statistical significant differences between aspirin sensitive and aspirin tolerant asthma in mean prebronchodilator FEV1 values and ACT scores before and after the treatment. Conclusion: According to this study aspirin sensitivity was not associated with poor response to standard treatment in patients with moderate or severe asthma.
- Subjects
DRUG side effects; ASPIRIN; ASTHMA in children; ASTHMA treatment
- Publication
Iranian Journal of Allergy, Asthma & Immunology, 2018, Vol 17, p147
- ISSN
1735-1502
- Publication type
Abstract