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- Title
Targeting uroporphyrinogen decarboxylase for head and neck cancer treatment.
- Authors
Ito, Emma; Shijun Yue; Moriyama, Eduardo H.; Hui, Angela B.; Inki Kim; Wei Shi; Alajez, Nehad M.; Bhogal, Nirmal; GuoHua Li; Datti, Alessandro; Schimmer, Aaron D.; Wilson, Brian C.; Liu, Peter P.; Durocher, Daniel; Neel, Benjamin G.; O'Sullivan, Brian; Cummings, Bernard; Bristow, Rob; Wrana, Jeff; Fei-Fei Liu
- Abstract
The article offers information on the uroporphyrinogen decarboxylase (UROD) used for treating the head and neck cancer (HNC). It mentions that an RNA interference (RNAi)-based radiosensitizer high-throughput screen (HTS) was conducted for identifying the novel genes that will sensitize HNC cells to ionizing radiation. It also reveals that the UROD serves as a potent tumor-selective sensitizer for radiation.
- Subjects
UROPORPHYRINOGEN decarboxylase; HEAD &; neck cancer treatment; RNA interference; GENES; TUMORS; IONIZING radiation
- Publication
BMC Proceedings, 2013, Vol 7, Issue Suppl 2, p1
- ISSN
1753-6561
- Publication type
Article
- DOI
10.1186/1753-6561-7-S2-P19