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- Title
Graves' Disease: Acquired Cause of a Moderate Increase in Hemoglobin A2 Level.
- Authors
Salah-Elkheir, Soukaina; Elmachtani-Idrissi, Samira; Bouhsain, Sanae; Dami, Abdellah; Biaz, Asmaa
- Abstract
Background: Hyperthyroidism can lead to diverse hematological disorders, such as microcytosis and a mild increase in hemoglobin A2 fraction. Methods: This study reported a 31-year-old woman of Moroccan origin recently diagnosed with Graves' disease. Her blood tests revealed microcytosis, hypochromia, and a normal ferritin level. A phenotypic analysis of hemoglobin was performed using two techniques: capillary electrophoresis and reversed-phase high performance liquid chromatography. Results: Both techniques indicated a slight increase in hemoglobin A2 level. These results initially suggested heterozygous beta-thalassemia, eventually correlating with the concurrent presence of Graves' disease, as evidenced by the normalization of hemoglobin A2 level following treatment. Conclusions: This case highlights the importance of having clinical, biological, and therapeutic data for a relevant interpretation of a phenotypic hemoglobin study.
- Subjects
FETAL hemoglobin; HIGH performance liquid chromatography; HEMOGLOBINS; BLOOD diseases; CAPILLARY electrophoresis
- Publication
Clinical Laboratory, 2024, Vol 70, Issue 5, p1031
- ISSN
1433-6510
- Publication type
Article
- DOI
10.7754/Clin.Lab.2023.231201