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- Title
Synthesis of Aza‐Bicyclic Maleimide Skeleton by Addition‐Ring Opening Cascade Reaction of Vinylogous Oxindole.
- Authors
Liao, Qian; Zhang, Yang; Liu, Jin‐Yu; Li, Qing‐Song; Huang, Yu‐Min
- Abstract
An efficient method has been developed to facilitate the addition‐ring opening cascade reaction of vinylogous oxindole, resulting in the synthesis of a variety of aza‐bicyclic maleimide derivatives with high yields and exceptional diastereoselectivities. Furthermore, the product could be effectively and easily transformed into the difluoromethylenecyclohexane skeleton through a dehydrofluorination process. This methodology demonstrates significant potential for the synthesis of aza‐bicyclic maleimide skeleton, which possesses biological or pharmaceutical activity.
- Subjects
SKELETON; INDOLE derivatives; RING-opening reactions
- Publication
European Journal of Organic Chemistry, 2024, Vol 27, Issue 20, p1
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202400195