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- Title
Palladium‐Catalyzed Cascade Carbonylative Synthesis of Functionalized Isoquinoline‐1,3‐diones and Oxindoles Using Dimethyl Carbonate as both Solvent and Reactant.
- Authors
Wen, D.; Shen, Z.; Qi, X.; Wu, X.‐F.
- Abstract
Dimethyl carbonate (DMC), a non‐toxic liquid, which shows diverse and tunable reactivity in organic synthesis. Herein, we report a nice study on using DMC as both solvent and reactant in palladium‐catalyzed intramolecular Heck/Carbonylation for the synthesis of functionalized isoquinoline‐1,3‐diones and oxindoles. To avoid the usage of toxic CO gas, formic acid is employed as the CO source, and a variety of functionalized isoquinoline‐1,3‐diones and oxindoles were obtained in very good yields.
- Subjects
OXINDOLES; FORMIC acid; ETHANES; CARBONATES; BIOCHEMICAL substrates; SOLVENTS
- Publication
European Journal of Organic Chemistry, 2022, Vol 2022, Issue 42, p1
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202200971