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- Title
Pharmacological basis for the antihypertensive activity of Grewia asiatica fruit extract.
- Authors
Akram, Zuneera; Perveen, Rehana; Siddiqi, Hasan Salman; Hussain, Muzammil; Imam, Shahlla; Abrar, Hina; Mahmood, Syed Mohammad
- Abstract
In the management of cardiovascular disorders, medicines from herbal sources have played a vital role through centuries. The following study was commenced in order to lay possible pharmacological foundation associated with medicinal uses of edible fruit of Grewia asiatica in hypertension through in-vitro method. In this study isolated atrial preparation of Guinea pig was used where crude ethanolic extract of Grewia asiatica fruit (Ga.Cr) decreased the force and rate of spontaneous atrial contractions (0.03-10mg/kg). In isolated rat aortic ring preparations previously vasoconstricted by phenylephrine and High K+, it also resulted in dose dependent vasodilation (0.01-10 mg/kg). In the presence of L-NAME, the relaxation curve of Ga.Cr was partially inhibited showing involvement of Nitric oxide (NO) mediated pathway. The speculative analysis contemplated that Ga.Cr has blood pressure reducing potentials through inhibition of Ca++ influx via Ca++ channels, its release from intracellular stores and through other means like NO mediated pathways.
- Subjects
FRUIT extracts; BLOOD pressure; CARDIOVASCULAR diseases; HYPERTENSION; AORTA
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2021, Vol 34, Issue 4, p1429
- ISSN
1011-601X
- Publication type
Article
- DOI
10.36721/PJPS.2021.34.4.REG.1429-1436.1