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- Title
Differential regulation of renal cyclooxygenase mRNA by dietary salt intake.
- Authors
Jensen, Boye L.; Kurtz, Armin
- Abstract
Differential regulation of renal cyclooxygenase mRNA by dietary salt intake. Experiments were done to investigate the influence of dietary salt intake on renal cycloxygenase (COX) I and II mRNA levels. To this end rats were fed either a low NaCl diet (LS: 0.02% NaCl wt/wt) or a high NaCl diet (HS diet; 4% NaCl wt/wt) for 5, 10 and 20 days. After 10 days Na excretion differed 760-fold, plasma renin activity and renin mRNA were increased eight- and threefold in LS compared to HS animals. Total renal COX 1 mRNA decreased 50%- following the LS diet and did not change after the HS diet. Conversely. COX II mRNA declined after HS intake and transiently increased after salt depletion. COX I and II mRNAs were unevenly distributed along the cortical-medullary axis with ratios of the cortex;outer medulla;papilla of 1:3:23 and 1:1:2. respectively. Cortical COX mRNAs were inversely regulated by salt intake with eightfold changes in COX II. Conversely, in medullary zones. COX I mRNA correlated directly with salt intake. We conclude that dietary salt intake influences renal cyclooxygenase mRNAs zone-specifically with opposite responses between cortex and medulla. Cortical COX Il-mediated prostaglandin formation is probably important in low salt states whereas medullary COX I-produced prostaglandins seem to be more important for renal adaptation to a high salt intake.
- Subjects
CYCLOOXYGENASES; MESSENGER RNA; INFLAMMATORY mediators; RENIN; PROSTAGLANDINS; SALT
- Publication
Kidney International, 1997, Vol 52, Issue 5, p1242
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.1997.449