We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Osmoregulation in the renal papilla: membranes, messengers and molecules.
- Authors
Kinne, Rolf K. H.; Boese, Stefan H.; Kinne-Saffran, Evamaria; Ruhfus, Birgit; Tinel, Hanna; Wehner, Frank; Kinne, R K; Boese, S H; Kinne-Saffran, E; Ruhfus, B; Tinel, H; Wehner, F
- Abstract
This contribution summarizes recent progress in the understanding of the molecular basis of the release of organic osmolytes that occurs when inner medullary cells are confronted with a drop in osmolarity in their environment. For sorbitol release across the basolateral membrane an increase in intracellular calcium seems to be the prominent signal, initiated by G-protein activation, followed by phosphatidylcholine phospholipase activation and generation of arachidonic acid. The increase in betaine permeability is also G-protein dependent but calcium independent, and is restricted to the basal-lateral cell face. Myo-inositol and glycerophosphorylcholine efflux are calcium and G-protein independent and occur both across the apical and basolateral membrane, although to a different extent. Taurine release is also calcium and G-protein independent; a swelling-activated anion channel at the basolateral membrane represents the major efflux pathway.
- Subjects
OSMOREGULATION; RENAL papilla; SORBITOL; CALCIUM ions; G proteins; ARACHIDONIC acid; KIDNEY physiology; ANIMALS; CELL membranes; CELLULAR signal transduction; KIDNEYS; WATER-electrolyte balance (Physiology); PHYSIOLOGY
- Publication
Kidney International, 1996, Vol 49, Issue 6, p1686
- ISSN
0085-2538
- Publication type
journal article
- DOI
10.1038/ki.1996.248