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- Title
Effect of Laser Moxibustion for Knee Osteoarthritis: A Multisite, Double-blind Randomized Controlled Trial.
- Authors
Ling Zhao; Ke Cheng; Fan Wu; Jiong Du; Yue Chen; Tan, Ming T.; Lixing Lao; Xueyong Shen; Zhao, Ling; Cheng, Ke; Wu, Fan; Du, Jiong; Chen, Yue; Lao, Lixing; Shen, Xueyong
- Abstract
<bold>Objective: </bold>To examine the effects of laser moxibustion on pain and function in patients with knee osteoarthritis (OA).<bold>Methods: </bold>A double-blind randomized clinical trial (4-week treatment, 20-week follow-up) was conducted. A total of 392 symptomatic knee OA patients with moderate to severe clinically significant knee pain were randomly assigned to laser treatment or sham laser control group (1:1). Twelve sessions of laser moxibustion or sham laser treatments on the acupuncture points at the affected knee(s) were performed 3 times a week for 4 weeks. The primary outcome measurement was change in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain score from baseline to Week 4.<bold>Results: </bold>Among the 392 randomized participants, 364 (92.86%) completed the trial. The median WOMAC pain score decreased significantly at Week 4 in the active group than in the sham group (2.1, 95% CI 1.6-2.6, P < 0.01). At Week 24, compared to the sham laser, active laser treatment resulted in significant pain reduction and function improvement (3.0, 95% CI 2.5-3.6, P < 0.01, and 14.8, 95% CI 11.9-17.6, P < 0.01, respectively). The physical component of the quality of life significantly improved in the active group vs the sham controls at Week 4 (3.2, 95% CI 1.3-5.0, P = 0.001) up to Week 24 (5.1, 95% CI 3.3-7.0, P < 0.001). No serious adverse effects were reported.<bold>Conclusion: </bold>Laser moxibustion resulted in statistically and clinically significant pain reduction and function improvement following a 4-week treatment in patients with knee OA.
- Subjects
MOXIBUSTION; ACUPUNCTURE points; RANDOMIZED controlled trials; OSTEOARTHRITIS treatment; KNEE diseases; RESEARCH; LASERS; RESEARCH methodology; MEDICAL cooperation; EVALUATION research; COMPARATIVE studies; QUALITY of life; KNEE
- Publication
Journal of Rheumatology, 2021, Vol 48, Issue 6, p924
- ISSN
0315-162X
- Publication type
journal article
- DOI
10.3899/jrheum.200217