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- Title
Cellular therapies: what is still missing?
- Authors
Pinkernell, Kai
- Abstract
Yeagy and colleagues present long-term data from a preclinical model of cystinosis after hematopoietic stem cell transplantation. The results suggest a therapeutic benefit independent of target tissue differentiation but dependent on the level of bone marrow chimerism. The mode of action remains mysterious, but positive effects are seen. Although the work presents a potential therapeutic option for an otherwise dismal disease, the search for the mechanism of action in cellular therapies continues.
- Subjects
CELLULAR therapy; CYSTINOSIS; HEMATOPOIETIC stem cell transplantation; BONE marrow; KIDNEY disease treatments
- Publication
Kidney International, 2011, Vol 79, Issue 11, p1161
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.2011.37