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- Title
Treatment of multiple sclerosis: beyond the NICE guidelines.
- Authors
A. Chaudhuri; P.O. Behan
- Abstract
Multiple sclerosis (MS) is a common, disabling neurological condition whose pathogenesis is not clearly understood. Although current treatment recommendations assume an immunopathogenic disease mechanism, MS may not be an autoimmune disorder. Long-term immunological therapy for MS is in our view an untested approach, guided by uncritical acceptance of data from drug trials. We do not believe that there is convincing evidence that any of these immune-based treatments prevents long-term disease progression, or has much effect on common disabilities such as fatigue, pain, depression and cognitive impairment. The recent recommendations of the National Institute of Clinical Excellence did not address important issues regarding disease modification, management of paroxysmal symptoms and the likely therapeutic candidates for future treatment trials. We discuss treatment options for MS beyond the NICE guidelines.
- Subjects
MULTIPLE sclerosis; DISEASES; DEPRESSED persons; VIRUS diseases
- Publication
QJM: An International Journal of Medicine, 2005, Vol 98, Issue 5, p373
- ISSN
1460-2725
- Publication type
Article
- DOI
10.1093/qjmed/hci059