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- Title
HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy.
- Authors
Corder, Elizabeth H.; Robertson, Kevin; Lannfelt, Lars; Bogdanovic, Nenad; Eggertsen, Gösta; Wilkins, Jean; Hall, Colin
- Abstract
HIV produces a chronic viral infection of the central nervous system that elicits chronic glial activation and overexpression of glial cytokines1?5 that are also implicated in Alzheimer disease (AD) pathogenesis6?11. A genetic risk factor for AD is the E4 isoform for apolipoprotein E (APOE)12,13. Here we compare the frequency of neurologic symptoms for subjects with and without the E4 isoform (E4(+)and E4(?), respectively) in an HIV cohort14?17. Compared with E4(?) subjects, twice as many E4(+) subjects were demented (30% compared with 15%) or had peripheral neuropathy (70% compared with 39%) at least once, and they had threefold more symptomatic examinations (13% compared with 3% and 42% compared with 14%, respectively)(P < 0.0001). Thus, neurologic symptoms for HIV-infection and AD are linked through an etiologic risk factor. Long-term survivors of HIV infection with E4 may be at high risk for AD; conversely, gene?viral interactions may speed AD pathogenesis.
- Subjects
HIV infections; DEMENTIA; NEUROPATHY; ALZHEIMER'S disease; APOLIPOPROTEIN E
- Publication
Nature Medicine, 1998, Vol 4, Issue 10, p1182
- ISSN
1078-8956
- Publication type
Article
- DOI
10.1038/2677