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- Title
Influence of a low dose of amphetamine on vesicular monoamine transporter binding: A PET (+)[<sup>11</sup>C]DTBZ study in humans.
- Authors
Boileau, Isabelle; Houle, Sylvain; Rusjan, Pablo M.; Furukawa, Yoshiaki; Wilkins, Diana; Tong, Junchao; Selby, Peter; Wilson, Alan A.; Kish, Stephen J.
- Abstract
We previously reported increased binding of (+)[11C]DTBZ (dihydrotetrabenazine), the vesicular monoamine transporter (VMAT2) positron emission tomography (PET) radioligand, in striatum of some methamphetamine users. This finding might be explained by stimulant-induced vesicular DA depletion resulting in decreased DA (+)[11C]DTBZ competition at VMAT2. In a prospective PET study, we now find that administration of an acute oral dose of amphetamine (0.4 mg/kg) to humans does not cause increased striatal (+)[11C]DTBZ binding but a slight 5% decrease. Our data suggest that a low amphetamine dose is unlikely to cause sufficient DA depletion to detect increased (+)[11C]DTBZ binding and that a higher dose might be required. Synapse 64:417-420, 2010. © 2010 Wiley-Liss, Inc.
- Publication
Synapse, 2010, Vol 64, Issue 6, p417
- ISSN
0887-4476
- Publication type
Article
- DOI
10.1002/syn.20743