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- Title
Enhancement of the Physicochemical Properties of Poorly Soluble Lovastatin by Co-crystallization Techniques - In vivo Studies.
- Authors
MADHURI, GADDAM; NAGARAJU, R.; KILLARI, K. N.
- Abstract
To overcome the poor solubility and low bioavailability of lovastatin co-crystallization was attempted. Lovastatin co-crystals were prepared with selected co-former gallic acid by co-grinding method. Characterization was carried out through X-ray diffraction, Fourier Transform infra-red spectroscopy, differential scanning colorimetry and scanning electron microscopy. The Fourier-transform infrared spectroscopy results showed that a hydrogen bond was formed between lovastatin and gallic acid to yield a co-crystal. Micrometric properties, solubility, dissolution studies, pre-compression and post-compression properties were evaluated. Lovastatin co-crystals were formulated into conventional tablets. In vivo and stability studies were performed. Pharmacokinetic parameters and dynamic studies of the formulation were statistically analysed and a value of p<0.05 was considered to be significant. Thus physicochemical properties and bioavailability of lovastatin was improved through co-crystallization.
- Subjects
CRYSTALLIZATION; LOVASTATIN; FOURIER transform spectroscopy; IN vivo studies; DRUG solubility; GALLIC acid; COLORIMETRY
- Publication
Indian Journal of Pharmaceutical Sciences, 2020, Vol 82, Issue 2, p249
- ISSN
0250-474X
- Publication type
Article
- DOI
10.36468/pharmaceutical-sciences.645