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- Title
Emerging Topics in Protein Crystallography.
- Authors
Chen, Zhongzhou; Zanotti, Giuseppe
- Abstract
Protein crystallography is a discipline that focuses on determining the three-dimensional structure of biological macromolecules in a crystalline state. It has undergone significant technological advancements over the past seventy years, thanks to the parallel development of computing systems and X-ray sources. The field has seen a tremendous increase in the number of resolved structures, with over 218,000 structures deposited in the Protein Data Bank. Cryo-electron microscopy has also emerged as a technique that allows the determination of macromolecular structures without the need for crystallization. While further developments are expected, the focus is shifting towards gaining new insights into the structure of macromolecules relevant to human health. The article highlights five contributions in a special issue, including methodological advancements and applied studies in protein crystallography.
- Subjects
PROTEIN crystallography; ZINC-finger proteins; MOLECULAR structure; PROTEIN structure prediction
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 10, p5311
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25105311