We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin.
- Authors
Raja, Erna; Clarin, Maria Thea Rane Dela Cruz; Yanagisawa, Hiromi
- Abstract
Matricellular proteins are secreted extracellular proteins that bear no primary structural functions but play crucial roles in tissue remodeling during development, homeostasis, and aging. Despite their low expression after birth, matricellular proteins within skin compartments support the structural function of many extracellular matrix proteins, such as collagens. In this review, we summarize the function of matricellular proteins in skin stem cell niches that influence stem cells' fate and self-renewal ability. In the epidermal stem cell niche, fibulin 7 promotes epidermal stem cells' heterogeneity and fitness into old age, and the transforming growth factor-β—induced protein ig-h3 (TGFBI)—enhances epidermal stem cell growth and wound healing. In the hair follicle stem cell niche, matricellular proteins such as periostin, tenascin C, SPARC, fibulin 1, CCN2, and R-Spondin 2 and 3 modulate stem cell activity during the hair cycle and may stabilize arrector pili muscle attachment to the hair follicle during piloerections (goosebumps). In skin wound healing, matricellular proteins are upregulated, and their functions have been examined in various gain-and-loss-of-function studies. However, much remains unknown concerning whether these proteins modulate skin stem cell behavior, plasticity, or cell–cell communications during wound healing and aging, leaving a new avenue for future studies.
- Subjects
WOUND healing; SKIN aging; EXTRACELLULAR matrix proteins; STEM cell niches; PERIOSTIN; SKIN proteins; SKIN; HAIR follicles
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 18, p14274
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms241814274