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- Title
The Medication Risk of Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis in Asians: The Major Drug Causality and Comparison With the US FDA Label.
- Authors
Wang, Yu‐Hsin; Chen, Chun‐Bing; Tassaneeyakul, Wichittra; Saito, Yoshiro; Aihara, Michiko; Choon, Siew Eng; Lee, Haur Yueh; Chang, Mimi Mee; Roa, Francisca D.; Wu, Cheng‐Wei; Zhang, Jing; Nakkam, Nontaya; Konyoung, Parinya; Okamoto‐Uchida, Yoshimi; Cheung, Christina Man‐tung; Huang, Jin‐wen; Ji, Chao; Cheng, Bo; Hui, Rosaline Chung‐Yee; Chu, Chia‐Yu
- Abstract
Specific ethnic genetic backgrounds are associated with the risk of Stevens–Johnson syndrome / toxic epidermal necrolysis (SJS/TEN) especially in Asians. However, there have been no large cohort, multiple‐country epidemiological studies of medication risk related to SJS/TEN in Asian populations. Thus, we analyzed the registration databases from multiple Asian countries who were treated during 1998–2017. A total 1,028 SJS/TEN cases were identified with the algorithm of drug causality for epidermal necrolysis. Furthermore, those medications labeled by the US Food and Drug Administration (FDA) as carrying a risk of SJS/TEN were also compared with the common causes of SJS/TEN in Asian countries. Oxcarbazepine, sulfasalazine, COX‐II inhibitors, and strontium ranelate were identified as new potential causes. In addition to sulfa drugs and beta‐lactam antibiotics, quinolones were also a common cause. Only one acetaminophen‐induced SJS was identified, while several medications (e.g., oseltamivir, terbinafine, isotretinoin, and sorafenib) labeled as carrying a risk of SJS/TEN by the FDA were not found to have caused any of the cases in the Asian countries investigated in this study.
- Subjects
STEVENS-Johnson Syndrome; ASIANS; UNITED States. Food &; Drug Administration; STRONTIUM; BETA-lactamase inhibitors
- Publication
Clinical Pharmacology & Therapeutics, 2019, Vol 105, Issue 1, p112
- ISSN
0009-9236
- Publication type
Article
- DOI
10.1002/cpt.1071