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- Title
Hepatic PLIN5 Deficiency Impairs Lipogenesis through Mitochondrial Dysfunction.
- Authors
Zhang, Enxiang
- Abstract
Regulation of lipid droplets (LDs) metabolism is the core of controlling intracellular fatty acids (FAs) fluxes, and perilipin 5 (PLIN5) plays a key role in this process. Our previous studies have found that hepatic PLIN5 deficiency reduces LDs accumulation, but the trafficking of FAs produced from this pathway and the interaction between mitochondria and LDs in this process are largely unknown. Here, we found that the deficiency of PLIN5 decreases LDs accumulation by increasing FAs efflux. In addition, the decreased lipogenesis of PLIN5-deficient hepatocytes is accompanied by mitochondrial dysfunction, suggesting that PLIN5 plays an important role in mediating the interaction between LDs and mitochondria. Importantly, PLIN5 ablation negates oxidative capacity differences of peri-droplet and cytosolic mitochondria. In summary, these data indicate that PLIN5 plays a vital role in maintaining mitochondrial-mediated lipogenesis, which provides an important new perspective on the regulation of liver lipid storage and the relationship between PLIN5 and mitochondria.
- Subjects
LIPID synthesis; FATTY acids; MITOCHONDRIA; PERILIPIN; PLANT mitochondria; LIVER cells; METABOLISM
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 24, p15598
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms232415598