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- Title
O-Glycosylation is Increased in the Tubuli and Glomeruli of Patients with Diabetic Nephropathy.
- Authors
Cseh, Judit; Degrell, Péter; Fülöp, Norbert; Pajor, László; Chatham, John C.; Wittmann, István
- Abstract
There is increasing evidence that O-glycosylation (O-GlcNAc) plays an important role in cell signaling pathways. It has also been reported that increases in O-GlcNAc contributes to the development of diabetes and diabetic complications; however, little is known about O-GlcNAc levels in diabetic nephropathy (DNP). Therefore the goal of this study was to determine whether O-GlcNAc could be detected in human kidney biopsy specimens, and if so to examine whether O-GlcNAc levels were increased in the kidneys of patients with DNP compared to the non diabetic individuals. Using immunohistochemistry biopsy specimens of type-2 diabetic patients (n=6) and patients with previously diagnosed thin basement membrane nephropathy (n=7) serving as controls, O-GlcNAc was assessed by using CTD110.6 antibody. We showed for the first time that protein O-GlcNAc was detected in the human kidney. Furthermore, as shown in the table we found a significant increase in the number of O-GlcNAc positive tubuli and glomeruli in samples from diabetic subjects. Therefore in conclusion we propose that increased O-GlcNAc levels may play an important role in the development of diabetic nephropathy.
- Publication
FASEB Journal, 2008, Vol 22, p160
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fasebj.22.2_supplement.160