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- Title
S-glutathiolation by peroxynitrite of p21ras at cysteine-118 mediates its direct activation and downstream signaling in endothelial cells.
- Authors
Clavreul, Nicolas; Adachi, Takeshi; Pimental, David R.; Yasuo Ido; Schöneich, Christian; Cohen, Richard A.
- Abstract
Presents the findings of a study on the role of direct oxidant-mediated S-glutathiolation of P21 renin-angiotensin system (P21ras) in regulating its activity. Contribution of peroxynitrite in promoting p21ras activation; Effect of S-glutathiolation on cysteine 118; Concentration of endogenous peroxynitrite in bovine aortic endothelial cell.
- Subjects
RENIN-angiotensin system; CYSTEINE proteinases; ENDOTHELIUM; OXIDIZING agents; ANGIOTENSINS
- Publication
FASEB Journal, 2006, Vol 20, Issue 3, p518
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fj.05-4875fje